Synthetic Strategies to Control C–N Atropisomerism in Acyclic Amines and Amides

Atropisomeric molecules are a privileged class of stereogenic material that have important applications in catalysis, materials science and medicines. To date, the majority work has been focused upon biaryl heterobiaryl scaffolds involving restricted rotation between pair cyclic fragments, but C–N atropisomeric based amines amides where nitrogen atom is not part ring system rapidly emerging as an molecules. This focus this Short Review article, which begins by discussing factors influence configurational stability such provides historical background to their synthesis. followed detailed discussion state-of-the-art catalytic asymmetric strategies now available access C–Nacyclic atropisomers including carboxamides, sulfonamides, sulfinamides, phosphamides diarylamines. A variety different synthetic approaches discussed kinetic resolution/desymmetrization, amination, C–H functionalization, N-functionalization, annulation.